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Peptide

MT-2

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Melanotan 2MT-2MT-II

A cyclic peptide analog of α-MSH that targets melanocortin receptors and is studied for its role in melanogenesis and related biological pathways in research settings. Premium Research Peptide.

Original price was: $34.99.Current price is: $31.49.

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How MT-2 Works

The Science, Simplified

Non-Selective Melanocortin Agonism

Melanotan II (MT-2) is a synthetic cyclic heptapeptide analog of the endogenous alpha-melanocyte-stimulating hormone (α-MSH). Unlike linear analogs, its cyclic structure provides high metabolic stability and potent binding to multiple melanocortin receptors (MC1R, MC3R, MC4R, and MC5R).
Key insight: MT-2 is distinguished by its sub-nanomolar potency, allowing it to trigger biological pathways at significantly lower concentrations than naturally occurring hormones in laboratory models.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Activation of the MC1R Pigmentation Pathway

The primary researched effect of Melanotan II is its interaction with the Melanocortin-1 Receptor (MC1R) located on melanocytes. This binding stimulates the synthesis of eumelanin, the dark brown/black pigment responsible for skin coloration.

Key insight: In clinical observations, MT-2-induced melanogenesis occurs independently of UV radiation, suggesting a protective mechanism that increases melanin density without the DNA damage typically associated with sun exposure.

Central MC4R Signaling & Metabolism

Beyond the skin, MT-2 crosses the blood-brain barrier to act on central MC3 and MC4 receptors. These receptors are critical regulators of energy homeostasis, appetite suppression, and sexual function.

Key insight: Research indicates that MC4R activation by MT-2 significantly influences erectile activity and libido in animal models, leading to the development of several derivative compounds specifically for sexual health research

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

Melanotan II research has documented several systemic effects, many of which are dose-dependent and related to its central nervous system activity.

🧿 Common Digestive Issues

30%

Nausea & GI Distress

mild

15%

Facial Flushing

mild

12%

Increased Libido

mild

Safety Advantage

Potency & Photo-Protection

  • Dose Efficiency: Because of its cyclic structure and high potency, effective research results are achieved with micro-doses, reducing the total metabolic burden.
  • Reduction in UV Urgency: Research suggests that increasing melanin density via MT-2 may reduce the biological "need" for UV exposure to achieve pigmentation.
  • Metabolic Neutrality: Unlike many stimulatory compounds, MT-2 does not typically elevate heart rate or blood pressure significantly at standard research doses.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for each component

🔬 Molecular Profile

Melanotan II Structure

CAS Number

121062-08-6

Molecular Formula

C50H69N15O9

Molecular Weight

1024.18 g/mol

Sequence

Ac-Nle-c[Asp-His-D-Phe-Arg-Trp-Lys]-NH2

Structure

Cyclic lactam

PubChem Databases

🧊 Storage Requirements

Melanocortin Receptor Affinity

Handling and storage requirements

MC1R

High affinity (pigmentation)

MC3R

Moderate (metabolism)

MC4R

High affinity (sexual function)

MC5R

Moderate (exocrine)

📊 Physical Properties

Formulation Characteristics

Handling and storage requirements

Appearance

White lyophilized powder

Solubility

Soluble in water, saline

Storage

2-8°C (refrigerated)

Reconstituted stability

30 days refrigerated

Frequently Asked Questions

Common questions about MT-2

Melanotan II is a synthetic version of the natural alpha-melanocyte-stimulating hormone. It was originally developed by researchers at the University of Arizona who were seeking a way to protect against skin cancer by inducing a protective tan without the need for harmful UV exposure
Melanotan 1 is a linear peptide that primarily targets skin pigmentation (MC1R). Melanotan II is cyclic, which makes it more stable and potent. Because MT-2 also hits the MC4 receptor, it has additional effects on appetite and libido that Melanotan 1 does not have.
Yes, research indicates that Melanotan II increases melanin production across the entire body. This includes existing moles and freckles, which may appear darker or more pronounced during the research period. These changes are generally reversible upon cessation.
In many research protocols, a "loading phase" is used to gradually build up the peptide levels in the system until the desired level of pigmentation is reached. Once achieved, a "maintenance phase" with less frequent administration is typically used to hold the results.
For laboratory accuracy, Melanotan II should be reconstituted with Bacteriostatic Water. It should be handled with care; the vial should not be shaken, as the peptide structure is delicate and can be "sheared" by aggressive movement.

Sources & References

Peer-reviewed research

British Journal of Dermatology

A randomized controlled trial of melanotan II in the induction of eumelanin synthesis in fair-skinned subjects

2006

Barnetson RS, et al.

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Urology

Synthetic melanotropic peptide initiates erections in men with psychogenic erectile dysfunction: double-blind, placebo controlled crossover study

1998

Wessells H, et al.

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Life Sciences

Evaluation of melanotan-II, a superpotent cyclic melanotropic peptide in a pilot phase-I clinical study

1996

Dorr RT, et al.

View Source

Peptides

Discovery and development of novel melanogenic drugs. Melanotan-I and -II

2006

Hadley ME, Dorr RT

View Source

International Journal of Impotence Research

An effect on the subjective sexual response in premenopausal women with sexual arousal disorder by bremelanotide (PT-141), a melanocortin receptor agonist

2004

Diamond LE, et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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