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Small Molecule Compound

SLU-PP-332

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BlendsPeptidesResearch chemicals

A synthetic small-molecule pan-ERR agonist that activates estrogen-related receptors to enhance mitochondrial biogenesis and cellular energy metabolism, studied for its exercise-mimetic and metabolic effects in preclinical research models. Premium Research Compound.

Original price was: $149.99.Current price is: $134.99.

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How SLU-PP-332 Works

The Science, Simplified

Estrogen-Related Receptor (ERR) Agonism

SLU-PP-332 is a potent agonist of the Estrogen-Related Receptors (specifically ERR$\alpha$, ERR$\beta$, and ERR$\gamma$). These receptors are the “master switches” for energy metabolism, typically activated during intense aerobic exercise.

Key insight: By activating these receptors, SLU-PP-332 tricks skeletal muscle into behaving as if it is undergoing a marathon. In research models, this has resulted in mice running 70% longer and 45% further than control groups, all without previous physical training.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Mitochondrial Biogenesis & Fat Oxidation

The compound forces cells to create new mitochondria (the cell's power plants) and increases the body's ability to burn fat for fuel.

Key insight: In studies on obese models, SLU-PP-332 administration led to a 12% loss in body weight over 28 days. Critically, the subjects maintained the same food intake and activity levels; the weight loss was purely a result of increased “metabolic idle,” meaning the body used more energy just to stay alive.

Muscle Fiber Transition

Research shows that SLU-PP-332 promotes a shift in muscle fiber composition, increasing the percentage of Type IIa oxidative fibers.

Key insight: These fibers are fatigue-resistant and highly efficient at utilizing oxygen. By increasing these specific fibers, the compound enhances metabolic flexibility—the body’s ability to switch between burning glucose and burning fat—which is a primary marker of high-level athletic fitness and metabolic health.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

As one of the newest compounds in the peptide and SARM space, SLU-PP-332 is currently in the preclinical stage. While the initial data is promising, researchers emphasize that it is still a "chemical probe" used for exploration.

🧿 Common Digestive Issues

0%

Appetite Suppression

mild

0%

Skeletal Toxicity

mild

100%

Metabolic Shift

mild

Safety Advantage

Non-Hormonal Pathway

  • No Estrogen Activity: Despite its name (Estrogen-Related Receptor), this compound does not bind to the classical estrogen receptors ($ER\alpha$ or $ER\beta$). It does not cause "feminizing" side effects or interfere with reproductive hormones.
  • Organ Protection: Initial trials suggest potential protective effects for the heart and kidneys by improving mitochondrial health in these energy-demanding organs.
  • Lack of Stimulation: Unlike traditional fat burners, it does not rely on the central nervous system or caffeine-like stimulants, meaning it doesn't cause jitters or heart palpitations in research models.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is SLU-PP-332?

Full Name

SLU-PP-332

Chemical Name

4-Hydroxy-N-(Z)-naphthalen-2...

Molecular Weight

290.32 g/mol

CAS Number

303760-60-3

PubChem CID

5404083

🧊 Storage Requirements

Stability Information

Capsule/Powder

(15-30°C)

Store at room temperature

Light Exposure

Keep in amber glass or opaque packaging.

Stability

High;

resistant to thermal degradation.

📊 Physical Properties

Development History

Classification

ERR Pan-Agonist

Status

Preclinical Research Chemical

Discovery

University of Florida / St. Louis University

Research Goal

Obesity, Type 2 Diabetes, Heart Failure

Frequently Asked Questions

Common questions about SLU-PP-332

Scientists often use this nickname because SLU-PP-332 activates the exact same genetic program that occurs during a workout. However, in research, it is technically an ERR Agonist. It doesn't build muscle "size" like a steroid, but it builds muscle "efficiency" and endurance like a marathon runner.
Unlike many metabolic enhancers, SLU-PP-332 is not a stimulant. It does not act on the brain's adrenaline pathways, so current research hasn't noted significant disruptions to sleep cycles, though most research dosing occurs during the subjects' active (waking) hours.
SARMs focus on the Androgen Receptor to increase muscle mass and strength. [SLU-PP-332 focuses on the Estrogen-Related Receptor to increase mitochondrial density and fat burning. They target completely different biological systems.
In animal models, it is highly effective for weight loss. It specifically prevents the accumulation of fat mass even when the subjects are on a "Western-style" high-fat diet.
SLU-PP-332 is currently an investigational research chemical. While it has shown an excellent safety profile in rodents, it has not yet completed human clinical trials and is not FDA-approved for human consumption.

Sources & References

Peer-reviewed research

  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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