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SERM Compound

Enclomephine

5.0 Reviews

EnclomephinePeptide

A selective estrogen receptor modulator (SERM) presented in 25 mg capsules, studied for its effects on endogenous testosterone regulation and hormonal balance in research settings. Premium Research Compound.

Original price was: $164.99.Current price is: $148.54.

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How Enclomephine Works

The Science, Simplified

Selective Estrogen Receptor Antagonism

Enclomiphene is the trans-isomer of clomiphene citrate. It acts as a selective antagonist at the estrogen receptors in the pituitary gland.
Key insight: By blocking the negative feedback of estrogen, it tricks the pituitary gland into signaling the body to produce more Luteinizing Hormone (LH) and Follicle-Stimulating Hormone (FSH). In research models, this results in a significant increase in natural, endogenous testosterone production while maintaining the body’s natural hormonal rhythm.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Preservation of Spermatogenesis

nlike exogenous testosterone replacement (TRT), which often shuts down sperm production, Enclomiphene supports the HPTA axis.

Key insight: Because it increases FSH levels, research indicates that Enclomiphene can raise testosterone levels while preserving or even improving sperm count and motility. This makes it a primary subject for studies involving fertility preservation and the treatment of secondary hypogonadism.

Isomeric Purity Advantage

Traditional Clomiphene (Clomid) is a mixture of two isomers: Enclomiphene (anti-estrogenic) and Zuclomiphene (pro-estrogenic).

Key insight: Zuclomiphene can stay in the system for months and may cause unwanted side effects like mood swings or vision issues. By providing pure Enclomiphene, researchers can study the beneficial effects of testosterone elevation without the “estrogenic baggage” or long-term accumulation associated with the Zu isomer.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

Enclomiphene (formerly known as Androxal during clinical trials) has a robust history of Phase II and Phase III human clinical trials, showing a generally high level of tolerability.

🧿 Common Digestive Issues

10%

Headache

mild

5%

Nausea

mild

4%

Joint Pain

mild

Safety Advantage

Non-Suppressive Elevation

  • HPTA Support: It does not cause the "shutdown" or testicular atrophy associated with synthetic steroids, as it stimulates the body's own production machinery.
  • Stable Blood Levels: With 100 capsules of 25mg, researchers can maintain consistent, daily protocols. Enclomiphene has a relatively short half-life (~10 hours), meaning it clears the system much faster than older isomers.
  • Vision Safety: Research suggests that pure Enclomiphene carries a lower risk of the visual disturbances (floaters or blurred vision) occasionally seen with mixed-isomer clomiphene.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for this 25mg capsule format

🔬 Molecular Profile

What Is Enclomephine?

Full Name

Enclomiphene Citrate

CAS Number

15690-57-0

Molecular Weight

405.9 g/mol

Formula

C26H28CINO

Format

25mg Oral Capsules

🧊 Storage Requirements

Stability Information

Capsule Form

(15-30°C)

Store in a cool, dry place

Light Sensitive

Yes

Keep in opaque or amber containers.

Shelf Life

Stable for 2 years

if kept away from moisture.

📋Research Status

Development History

Clinical Stage

Completed Phase III (Androxal)

Classification

SERM (Selective Estrogen Receptor Modulator)

Primary Goal

Secondary Hypogonadism / Fertility Research

US Status

Investigational Research Compound

Frequently Asked Questions

Common questions about Enclomephine

Not exactly. Clomid is a 60/40 mix of two isomers. Enclomiphene is the isolated "good" isomer that provides the testosterone-boosting effects. By removing the other isomer (Zuclomiphene), researchers can avoid the estrogenic side effects and long-term buildup associated with the original drug.
Because it raises testosterone, some of that testosterone will naturally aromatize into estrogen. However, because Enclomiphene is an estrogen receptor antagonist, it blocks those estrogen signals at the pituitary level, preventing the negative feedback loop that would normally shut down production.
In the research community, Enclomiphene is considered one of the most effective compounds for studying HPTA recovery. Its ability to rapidly restart LH and FSH production makes it a frequent subject for protocols aimed at restoring natural hormone levels after suppressive research.
Research indicates that LH and FSH levels begin to rise within days of the first dose, with peak testosterone levels typically observed after 2-4 weeks of consistent administration in clinical models.
No. While it successfully passed many clinical trials under the name Androxal, the FDA requested more data regarding long-term bone density and organ health. It remains an investigational research compound and is not intended for human consumption.

Sources & References

Peer-reviewed research

  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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