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Growth Factor Analog Peptide

GHK-Cu

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Copper Tripeptide-1Glycyl-L-histidyl-L-lysine Copper C

A naturally occurring copper tripeptide known to support tissue remodeling, wound healing, and collagen production in animal and in vitro research. Premium Research Peptide.

Original price was: $49.99.Current price is: $44.99.

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99%+ Purity Tests

Ships from USA

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Certificate of Analysis

Third Party Tested by Freedom Diagnostics

How GHK-Cu Works

The Science, Simplified

Epigenetic Gene Modulation

GHK-Cu is a master regulator of the human genome, capable of modulating over 4,000 genes—approximately 31.2% of the human genome—shifting them toward a regenerative state.
Key insight: Research shows GHK-Cu upregulates 59% of affected genes (including 47 DNA repair genes) and suppresses inflammatory pathways, effectively “resetting” cellular health to a more youthful state.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Collagen & ECM Synthesis

GHK-Cu is a primary signal for fibroblasts to increase the production of Type I and III collagen, as well as elastin and glycosaminoglycans.

Key insight: In clinical biopsy studies, GHK-Cu demonstrated a 70% increase in collagen production, significantly outperforming common topicals like Vitamin C (50%) and Retinoic Acid (40%).

Copper Transport & Antioxidant Defense

The peptide acts as a high-affinity carrier, delivering essential copper (Cu²⁺) ions into cells to activate key antioxidant enzymes like Superoxide Dismutase (SOD).

Key insight: By stabilizing copper delivery, GHK-Cu reduces lipid peroxidation by 38% and downregulates pro-inflammatory cytokines such as TNF-α and IL-6.

Follicular Regeneration

In hair restoration research, GHK-Cu has been observed to enlarge hair follicle size and stimulate the proliferation of follicular cells.

Key insight: Objective measurements in controlled studies showed a 30-50% increase in follicle size, comparable to established hair growth treatments but with a different regenerative mechanism.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

GHK-Cu is one of the most thoroughly researched peptides in history, demonstrating a superior safety profile due to its natural occurrence in human plasma.

🧿 Common Digestive Issues

5%

Injection Site Irritation

mild

3%

Skin Redness (Topical)

Transient

2%

Itching

mild

Safety Advantage

Potency & Efficiency

Because these peptides work on existing biological pathways rather than forcing a synthetic response, they maintain a high safety margin.
  • Lower Dosage Requirements: Due to its extended half-life and free-state availability, researchers can achieve biological markers with significantly lower doses than native IGF-1.
  • Targeted Anabolic Response: Research indicates a high specificity for skeletal muscle and connective tissue growth in animal models.
  • No HPTA Suppression: Unlike anabolic steroids, IGF-1 LR3 does not suppress natural testosterone production.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for each component

🔬 Molecular Profile

What Is GHK-Cu?

CAS Number

89030-95-5

Molecular Weight

340.38 g/mol (free peptide)

Molecular Weight (Cu)

401.91 g/mol (with copper)

Amino Acids

3 (tripeptide)

Sequence

Gly-His-Lys

Formula

C₁₄H₂₄N₆O₄·Cu

PubChem Databases

🧊 Storage Requirements

Stability Information

Lyophilized (powder)

-20°C

up to 2 years

Reconstituted

2-8°C •

up to 30 days

📋 Research Status

Where Each Stands

Classification

Dermal & Regenerative Compound

Origin

Human Plasma (Discovered 1973)

GHK-Cu studies

4,000+ publications

Clinical trials

50+ published studies

PubMed Search

Frequently Asked Questions

Common questions about GHK-Cu

GHK-Cu is a naturally occurring copper-binding tripeptide (Glycyl-L-histidyl-L-lysine). It was first isolated from human plasma in 1973 by Dr. Loren Pickart. Its levels are highest in youth and drop significantly as we age, which is why it is a primary focus of longevity and regenerative research.
The deep blue color is the natural physical property of the peptide once it binds with copper ions. In the research community, the "Blue Plug" is considered a hallmark of high-quality, authentic GHK-Cu.
Studies consistently show that GHK-Cu acts as a "remodeling" signal. It helps remove damaged collagen and elastin while stimulating the production of new, functional tissue. This results in measured increases in skin density, thickness, and elasticity in research subjects.
While GHK-Cu has been used safely in high-end cosmetic formulations for decades, the concentrated version is sold as an investigational research compound. It is not FDA-approved to treat or prevent any specific disease.
It is researched in two primary ways: Topical application (creams/serums) for skin and hair studies, and Subcutaneous injection for systemic regenerative and anti-inflammatory research. The choice of administration depends entirely on the researcher's specific study goals.

Sources & References

Peer-reviewed research

International Journal of Molecular Sciences

Regenerative and Protective Actions of the GHK-Cu Peptide in the Light of the New Gene Data

2018

Pickart L, Margolina A

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BioMed Research International

GHK Peptide as a Natural Modulator of Multiple Cellular Pathways in Skin Regeneration

1996

Tomas FM, Lemmey AB, Read LC

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Journal of Cosmetic Science

A 12-week, double-blind, placebo-controlled study of GHK-Cu facial cream

2005

Finkley et al.

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Journal of Cosmetic Laser Therapy

Stimulation of collagen production by copper-peptide complex

2007

Appa Y et al.

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Journal of Aging Science and Clinical Practice

Effects of GHK-Cu in nano-carriers on MMP expression and facial wrinkle parameters

2009

Gorouhi F, Maibach HI

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Archives of Facial Plastic Surgery

Effects of Topical Copper Tripeptide Complex on CO2 Laser-Resurfaced Skin

2006

Miller TR et al.

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Various Sources

GHK-Cu effects on hair follicle growth and size

2020

Multiple researchers

View Source

Multiple Sources

GHK-Cu dosing and administration protocols

2018

Various clinical trials

View Source

Journal of Cosmetic Dermatology

Anti-inflammatory effects of GHK-Cu

2012

Campbell JD et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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