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Metabolic Peptide

MOTS-C

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Mitochondrial ORF of the 12S rRNA type-cMOTS-CMRWQEMGYIFYPRKLRPeptide

A mitochondria-derived peptide that influences metabolic function, with notable effects on exercise metabolism observed in rodent studies. Premium Research Peptide.

Original price was: $69.99.Current price is: $62.99.

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How MOTS-C Works

The Science, Simplified

The Master Metabolic Switch

MOTS-c is a 16-amino acid peptide encoded within the mitochondrial genome rather than the cell nucleus. Its primary action in research is the activation of AMPK (AMP-activated protein kinase), which is the body’s master switch for energy metabolism.
Key insight: In rodent studies, MOTS-c has demonstrated “exercise mimetic” effects, replicating the metabolic benefits of physical activity. One landmark study showed that aged mice treated with MOTS-c increased their running time by 2-fold and running distance by 2.16-fold, essentially reversing physical decline without additional training.
GE
Primary

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

COL
Strongest

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Cu²⁺
Supportive

Gene Expression

Epigenetic Modulation

Upregulates 59% of affected genes Activates 47 DNA repair genes Suppresses inflammatory pathways

Glucose Uptake & Insulin Sensitivity

By targeting the Folate-AICAR-AMPK pathway, MOTS-c promotes glucose uptake into skeletal muscle and enhances fatty acid oxidation (fat burning)

Key insight: Research has shown that MOTS-c can prevent diet-induced obesity and restore insulin sensitivity in middle-aged models. In humans, natural MOTS-c levels have been found to be significantly lower in obese subjects and elderly individuals, suggesting that its decline is a major factor in metabolic aging.

Nuclear Gene Regulation

Unique among peptides, MOTS-c can translocate to the cell nucleus during times of metabolic stress to regulate the expression of nuclear genes.

Key insight: This “retrograde signaling” allows the mitochondria to communicate with the nucleus to promote metabolic adaptation and cellular resilience. This mechanism is being researched for its potential to protect against vascular calcification and support bone health by inhibiting bone-destroying osteoclasts.

Wrinkle Reduction Comparison

Safety Profile from Research

What clinical studies report

MOTS-c has a strong safety profile in preclinical research, largely because it is a naturally occurring hormone already found in human plasma and skeletal muscle.

🧿 Common Digestive Issues

15%

Fatigue

mild

10%

Nausea

mild

8%

Headache

mild

Safety Advantage

Non-Suppressive Elevation

  • Naturally Present: MOTS-c is present in human breast milk and circulates in the blood, indicating it is a standard biological component with a high tolerance threshold.
  • Non-Toxic: No lethal dose (LD50) has been established in animal models, and no serious adverse events have been reported in published preclinical literature.
  • Analog Success: A synthetic analog of MOTS-c (CB4211) successfully completed Phase 1a human trials, proving to be safe and well-tolerated in healthy volunteers.

📊 Discontinuation Rates

🚫 Trial Exclusions

⚡ Regulatory Status

💡 Researcher Notes

Compound Information

Technical specifications for this 25mg capsule format

🔬 Molecular Profile

What Is MOTS-c?

Type

Mitochondrial-derived peptide

Amino Acids

16

Sequence

MRWQEMGYIFYPRKLR

Molecular Weight

2,174.6 g/mol

Formula

C101H152N28O22S2

Encoded in

12S rRNA (mtDNA)

🧊 Storage Requirements

Stability Information

Lyophilized (powder)

-20°C

stable long-term

Reconstituted

2-8°C

use immediately

Room temperature

Degrades 85-90% in 2-3 hrs

📋Research Status

Development History

Classification

Exercise Mimetic / Metabolic Peptide

Primary Target

AMPK Pathway / Skeletal Muscle

US Status

Investigational Research Compound

Key Research

Longevity, Obesity, NAFLD, Performance

Frequently Asked Questions

Common questions about MOTS-C

They work on different pathways. Cardarine targets the PPAR-delta pathway, while MOTS-c activates the AMPK pathway. In research, MOTS-c is often seen as more "foundational" because it is a natural signaling hormone produced by your own mitochondria, whereas Cardarine is a synthetic SARM-like compound.
Because it triggers the exact same metabolic response in your cells as a session of high-intensity aerobic exercise. It essentially forces the body to burn fat and take up glucose as if you were running, even while at rest.
Yes, it is a major focus of longevity research. Studies have shown that supplementing aged mice with MOTS-c can increase median lifespan by 6.4% and significantly improve physical performance in the later stages of life.
In a lab setting, should be kept in the freezer until the exact moment of use. Once reconstituted with Bacteriostatic Water, it should be used as soon as possible, as its biological activity begins to drop rapidly once it is no longer in its freeze-dried state.
No. It was only discovered in 2015 at USC. While analogs are currently in Phase 1b clinical trials for fatty liver disease, MOTS-c remains an investigational research compound and is not approved for human use.

Sources & References

Peer-reviewed research

Cell Metabolism

The Mitochondrial-Derived Peptide MOTS-c Promotes Metabolic Homeostasis and Reduces Obesity and Insulin Resistance

2015

Lee C, Zeng J, Drew BG et al.

View Source

Nature Communications

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

2021

Reynolds JC, Lai RW, Woodhead JST et al.

View Source

Alzheimer's Drug Discovery Foundation

MOTS-c Cognitive Vitality Report

2021

ADDF Aging and Alzheimer's Prevention Program

View Source

Aging Cell

The mitochondrial-derived peptide MOTS-c: a player in exceptional longevity?

2015

Fuku N, Pareja-Galeano H, Zempo H et al.

View Source

Physiol Rep

The mitochondrial-derived peptide MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity

2019

Kim S-J, Miller B, Mehta HH et al.

View Source
  • Important Research Notice

Not for human consumption. This product is sold exclusively for research and educational purposes. It is not intended to diagnose, treat, cure, or prevent any disease.

All clinical trial data and research findings presented on this page are sourced from peer-reviewed journals and official publications. They are provided for educational reference only and should not be interpreted as medical advice or product claims.

By purchasing this product, you confirm that you are a qualified researcher and will use it in accordance with all applicable laws and regulations.

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